Keywords aplastic anemia, chloramphenicol, mice, shrimps. Pengaruh residu khloramfenikol dalam udang windu terhadap kejadian anemia aplastik pada. Sari Pediatri, Vol. 7, No. 1, Juni Judul: Masalah pada Tata Laksana Anemia Aplastik. Background: Aplastic anemia is a well-recognized form of marrow failure. The incidence of aplastic anemia is subjected to wide variation.

Author: Mibar Dill
Country: Luxembourg
Language: English (Spanish)
Genre: Art
Published (Last): 5 December 2010
Pages: 435
PDF File Size: 18.97 Mb
ePub File Size: 13.41 Mb
ISBN: 522-1-61893-330-6
Downloads: 66538
Price: Free* [*Free Regsitration Required]
Uploader: Goltilrajas

Frickhofen N, Rosenfeld SJ. Homozygosis for 12 CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. Immune attack leads to marrow failure. Current status of allogeneic bone marrow transplantation in acquired aplastic anemia.


Therefore the aim of this study was to prove that chloramphenicol residue in shrimps for human consumption influences the appearance of aplastic anemia. MDS Aneuploidy develops in a minority of patients treated with immunosuppression over time, usually monosomy 7 and trisomy 8[ 32 ]. However, the study of idiosyncratic drug reactions, by definition extremely rare, is difficult and the only clear predisposition to abnormal drug metabolism underlying susceptibility is one study of a single individual exposed to carbamazepine published over 20 years ago [ 5 ].

A Prospective Multicentric Study. Clinically, r-ATG appears to be more immunosuppressive as a more prolonged lymphopenia is observed with this agent compared to h-ATG [ 52 ]. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: Isolation, Aneia, Adipogenic, and Osteogenic Differentiation.


New England Journal of Medicine. Hypocellular marrow with fat space aspiration 10X, Leishman stain Microscopically the aspiration material showed a small nodular area “hot spots” consisting of all types of marrow cell, which in turn was surrounded by large fatty spaces Click here to view.

Medical Journal of Lampung University

Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. For relapsed patients, re-introduction of CsA commonly result in improvement in blood counts, however, CsA-dependence is frequent and the dose of CsA anemiz is tapered slowly with hematologic monitoring [ 45 ].

However, we have noted a striking improvement in survival among non-responders to initial h-ATG treated at our institution in recent years [ 59 ]. Available from Accessed July 10,at http: Immunosuppressive drug treatment or enhancement of regulatory T cell function protected animals from the development of bone marrow failure.

In most cases, AA behaves as an immune-mediated disease.

In a mouse model of immune-mediated marrow failure, addition of T regulatory cells abrogated pancytopenia induced by the infusion of lymph node cells [ 14 ]. Aneuploidy develops in a minority of patients treated with immunosuppression over time, usually monosomy 7 and trisomy 8[ 32 ].

Very few clinical trials have specifically addressed moderate disease. Hematopoiesis Immune attack leads to marrow failure. Tinggalkan Balasan Batalkan balasan Ketikkan komentar di sini Golongan Tetrasiklin dan Khloramfenikol, Farmakologi dan Terapi.

Sao Paulo Medical Journal. Why T-cells are activated in AA is unclear. Accessed October 28,at: The blood Hb and er ythrocyte cellular form normalconditions at the end of the experiment was indicative of resistancedue continuous consumption followed by the formation of newnormochrome normocyter erythrocytes.


Evidence has accumulated in the recent years further corroborating an immune-mediated process underlying AA pathogenesis. Increased apoptosis in aplastic anemia bone marrow progenitor cells: Relapse of aplastic anaemia after immunosuppressive treatment: A common hematological abnormality among peripheral pancytopenia. See other articles in PMC that cite the published article.

How to cite this article: A cross-sectional study had been conducted for a period of one year among 5 to 70 years age group. Prospective multicenter trial comparing repeated immunosuppressive therapy with stem cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia. Most patients with AA are now expected to survive regardless of the treatment modality employed. Bancroft JD, Gamble M.


Dengan melanjutkan menggunakan situs web ini, Anda setuju dengan penggunaan mereka. In moderate AA, the clinical course is variable: Aplastic Anemia, Acquired and Inherited. Masalah Khloramfenikol pada produksi udang di Indonesia. Aplastic anemia induced disc edema and visual loss in pregnancy: Five to ten percent of cases of AA follow an episode of seronegative hepatitis [ 8 ], but despite intensive efforts, an infectious agent has not been identified.

Author: admin